Keros Therapeutics Inc

Bristol Myers Squibb is counting on Reblozyl, the thalassemia drug it co-developed with Merck, to help drive top-line growth as legacy drug sales decline, with the treatment's sales nearing $1.3 billion in the first half of 2026, up 23% from the year-ago period. The drug's strong sales reflect solid uptake in first-line MDS-associated anemia, continued strength in the second-line setting and further penetration in the first-line RS-negative population. The FDA has accepted a supplemental biologics license application for Reblozyl with concomitant janus kinase inhibitor therapy in adult patients with myelofibrosis-associated anemia receiving red blood cell transfusions, supported by the late-stage INDEPENDENCE study, and granted a target action date of March 11, 2027. A phase III study called ELEMENT-MDS, evaluating Reblozyl in first-line non-transfusion dependent low or intermediate risk MDS associated anemia, is ongoing, with data expected in 2028. In the competitive landscape, Geron Corporation's Rytelo generated $57.5 million of revenues in the second quarter of 2026 and is expected to post 2026 sales of $220-$240 million, while Keros Therapeutics expects a $20 million development milestone payment from partner Takeda after dosing the first patient in the late-stage ELRiSE MF study.